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Diagnostic and epidemiological landscape of anaerobic bacteria in Europe, 2020-2023 (ANAEuROBE)
M. Boattini, G. Bianco, P. Bastos, VE. Mavromanolaki, S. Maraki, A. Spiliopoulou, V. Kakouris, Y. Kalchev, A. Budimir, B. Bedenić, Z. Rubic, M. Licker, C. Musuroi, E. Juhász, K. Kristóf, M. Pirs, I. Velimirovic, M. Berktold, A. Liptáková, A....
Language English Country Netherlands
Document type Journal Article, Multicenter Study, Observational Study
- MeSH
- Bacteria, Anaerobic * drug effects isolation & purification classification MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacterial Infections * epidemiology diagnosis microbiology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Retrospective Studies MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Geographicals
- Europe MeSH
INTRODUCTION: Despite being implicated in a wide spectrum of community- and healthcare-acquired infections, anaerobes have not yet been incorporated into systematic surveillance programs in Europe. METHODS: We conducted a multicentre retrospective observational study analysing all anaerobic strains isolated from blood cultures in 44 European Hospital Centres over a 4-y period (2020-2023). Diagnostic approach, epidemiology, and antimicrobial susceptibility according to EUCAST v. 15.0 were investigated. RESULTS: Our study included 14,527 anaerobes, most of which were Gram-positive (45%) or Gram-negative (40%) bacilli. MALDI-TOF coupled to mass spectrometry was the most widely used tool for species identification (98%). Antimicrobial susceptibility testing was performed in the vast majority of centres, using mostly gradient diffusion strip (77%) and disk diffusion (45%) methods according to EUCAST guidelines. The most prevalent species were Cutibacterium acnes (18.7%), Bacteroides fragilis (16.3%), Clostridium perfringens (5.3%), Bacteroides thetaiotaomicron (4.2%), Fusobacterium nucleatum (3.5%), and Parvimonas micra (3.4%). C. acnes showed high resistance to benzylpenicillin (18%), clindamycin (39%), and imipenem (19% and 13% by MIC methods and disk diffusion, respectively). B. fragilis showed high resistance to amoxicillin/clavulanate (24%), piperacillin/tazobactam (22% and 14% by MIC methods and disk diffusion, respectively), clindamycin (22% by both MIC methods and disk diffusion), meropenem (13%), and metronidazole (10%, only by disk diffusion). A similar resistance pattern was observed in B. thetaiotaomicron, Bacteroides ovatus, and Parabacteroides distasonis. C. perfringens showed high resistance to clindamycin (69% and 45% by MIC methods and disk diffusion, respectively), while benzylpenicillin and metronidazole maintained over 90% activity. F. nucleatum showed high resistance to benzylpenicillin (11%), while Fusobacterium necrophorum showed alarming rates of resistance to clindamycin (12%), meropenem (16%) and metronidazole (11%). CONCLUSIONS: This study presented an up-to-date analysis of the diagnostics and epidemiology of anaerobic bacteria in Europe, providing insights for future comparative analyses and the development of antimicrobial diagnostic and management strategies, as well as the optimization of current antibiotic treatments.
BIOSS Centre for Biological Signaling Studies University of Freiburg Freiburg Germany
CIBER de Enfermedades Infecciosas Instituto de Salud Carlos 3 Madrid Spain
Clinical Microbiology Laboratory Medicine Skåne Lund Sweden
Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy
Department of Clinical Microbiology Cliniques Universitaires Saint Luc Brussels Belgium
Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark
Department of Clinical Microbiology University Hospital Antwerp Edegem Belgium
Department of Clinical Microbiology University Hospital of Split Split Croatia
Department of Clinical Microbiology Vall d'Hebron Barcelona Hospital Campus Barcelona Spain
Department of Clinical Pathology Centro Hospitalar Universitário de Lisboa Central Lisbon Portugal
Department of Dental Microbiology Medical University of Warsaw Warsaw Poland
Department of Experimental Medicine University of Salento Lecce Italy
Department of Genetics and Microbiology Universitat Autònoma de Barcelona Bellaterra Spain
Department of Medical and Clinical Pharmacology Toulouse University Hospital Toulouse France
Department of Medical and Surgical Sciences University of Bologna Bologna Italy
Department of Medical Microbiology and Infection Prevention Amsterdam UMC Amsterdam The Netherlands
Department of Microbiology and Infection Control Akershus University Hospital Lørenskog Norway
Department of Microbiology and Laboratory Medical Immunology Medical University of Lodz Lodz Poland
Department of Microbiology Oslo University Hospital Oslo Norway
Department of Microbiology St Vincent's University Hospital Dublin Ireland
Department of Microbiology University Hospital Krakow Poland
Department of Microbiology University of Oslo Oslo Norway
Department of Microbiology University of Patras Medical School Patras Greece
Department of Paediatrics Agios Nikolaos General Hospital Crete Greece
Department of Public Health and Paediatrics University of Torino Turin Italy
Faculdade de Medicina Universidade de Lisboa Lisbon Portugal
Infectious Diseases Service Lausanne University Hospital Lausanne Switzerland
INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes Université Nantes France
Institut Micalis UMR 1319 Université Paris Saclay INRAe AgroParisTech Châtenay Malabry France
Institute of Hygiene and Medical Microbiology Medical University of Innsbruck Innsbruck Austria
Institute of Laboratory Medicine Semmelweis University Budapest Hungary
Institute of Medical Microbiology University of Zurich Zurich Switzerland
Laboratory of Microbiology University Hospital St George Plovdiv Bulgaria
Lisbon Academic Medical Centre Lisbon Portugal
Microbiology Service University Clinical Hospital of Valencia Valencia Spain
Microbiology Unit IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy
Regional Department of Clinical Microbiology University Hospital Waterford Waterford Ireland
Service de Microbiologie Clinique Hôpitaux Saint Joseph and Marie Lannelongue Paris France
Service of Microbiology Hospital Universitario de Gran Canaria Dr Negrín Las Palmas Spain
Serviço de Patologia Clínica Centro Hospitalar Universitário Lisboa Norte Lisbon Portugal
U O C Laboratory Analysis Unit A O U Policlinico San Marco Catania Italy
Université Limoges INSERM CHU Limoges UMR 1092 Limoges France
References provided by Crossref.org
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- $a Boattini, Matteo $u Department of Public Health and Paediatrics, University of Torino, Turin, Italy; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy; Lisbon Academic Medical Centre, Lisbon, Portugal. Electronic address: matteo.boattini@unito.it
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- $a Diagnostic and epidemiological landscape of anaerobic bacteria in Europe, 2020-2023 (ANAEuROBE) / $c M. Boattini, G. Bianco, P. Bastos, VE. Mavromanolaki, S. Maraki, A. Spiliopoulou, V. Kakouris, Y. Kalchev, A. Budimir, B. Bedenić, Z. Rubic, M. Licker, C. Musuroi, E. Juhász, K. Kristóf, M. Pirs, I. Velimirovic, M. Berktold, A. Liptáková, A. Krajcikova, P. Drevinek, A. Gryndlerova, M. Brzychczy-Wloch, A. Olechowska-Jarząb, F. Bielec, M. Brauncajs, E. Podsiadly, G. Nurzyńska, P. Zalas-Więcek, K. Riesbeck, HS. Andersson, T. Tønjum, JC. Berild, TM. Leegaard, AN. Rasmussen, K. Schønning, S. Glöckner, J. Rödel, MT. Badr, GA. Häcker, D. Stark, A. Hamprecht, A. Dudakova, J. Jantsch, S. Mancini, C. Quiblier, D. Jacot, G. Greub, T. Ferniani, S. Ambretti, M. Calvo, S. Stefani, R. Schade, E. Yusuf, SVK. Koeveringe, S. Vandamme, A. Verroken, H. Rodriguez-Villalobos, F. Duigou, S. Corvec, P. Floch, C. Massip, D. Chainier, O. Barraud, MB. Louissaint, A. Mizrahi, S. Ali, M. Doyle, C. Egan, S. McNicholas, J. Colomina-Rodriguez, I. Torres, RG. Luengo, MNL. Escartín, MBV. Perez, AV. Halperin, SF. García, R. Cantón, M. Seruca, VS. Mendes, D. Carvalho, R. Cavallo, JM. Cristino, C. Costa
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Leegaard, Truls Michael $u Division of Medicine and Laboratory Sciences, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Microbiology and Infection Control, Akershus University Hospital, Lørenskog, Norway
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Calvo, Maddalena $u U.O.C. Laboratory Analysis Unit, A.O.U. "Policlinico-San Marco", Catania, Italy
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Mizrahi, Assaf $u Service de Microbiologie Clinique, Hôpitaux Saint-Joseph & Marie-Lannelongue, Paris, France; Institut Micalis UMR 1319, Université Paris-Saclay, INRAe, AgroParisTech, Châtenay Malabry, France
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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