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Refining partial gland ablation for localised prostate cancer: the FALCON project
L. Rodriguez-Sanchez, X. Cathelineau, TM. de Reijke, P. Stricker, M. Emberton, A. Lantz, B. Miñana López, JL. Dominguez-Escrig, FJ. Bianco, G. Salomon, A. Haider, A. Mitra, A. Bossi, E. Compérat, R. Reiter, P. Laguna, G. Fiard, L. Lunelli, GR....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
AngioDynamics
PubMed
39905268
DOI
10.1111/bju.16669
Knihovny.cz E-zdroje
- MeSH
- ablace * metody MeSH
- delfská metoda MeSH
- konsensus MeSH
- lidé MeSH
- nádory prostaty * chirurgie patologie MeSH
- výběr pacientů MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: To provide a contemporary statement on focal therapy (FT) for localised prostate cancer (PCa) from an international and diverse group of physicians treating localised PCa, with the aim of overcoming the limitations of previous consensus statements, which were restricted to early adopters, and to offer direction regarding the various aspects of FT application that are currently not well defined. MATERIALS AND METHODS: The FocAL therapy CONsensus (FALCON) project began with a 154-item online survey, developed following a steering committee discussion and literature search. Invitations to participate were extended to a large, diverse group of professionals experienced in PCa management. From 2022 to 2023, a Delphi consensus study consisting of three online rounds was conducted using the Modified Delphi method. A 1-9 Likert scale was used for the survey, which was followed by an in-person expert meeting. The threshold for achieving consensus was set at 70% agreement/disagreement. Six main aspects of FT were covered: (i) patient selection; (ii) energy source selection; (iii) treatment approach; (iv) treatment evaluation and follow-up; (v) treatment cost and accessibility; and (vi) future perspectives. RESULTS: Of 246 initial participants, 148 (60%) completed all three rounds. Based on participant feedback, 27 new statements were added in the second round, and 33 questions related to personal expertise, for which consensus was not necessary, were excluded. After the third and final round, consensus had not been reached for 69 items. These items were discussed at the in-person meeting, resulting in a consensus of 57 additional items. Consensus was finally not reached on 12 items. Given the volume of data, the voting outcomes are summarised in this article, with a detailed breakdown presented in the form of figures and tables. CONCLUSIONS: The FALCON project delivered a significant consensus on the approach to FT for localised PCa. Additionally, it highlighted gaps in our knowledge that may provide guidance for future research.
1st Faculty of Medicine Charles University Prague Czech Republic
Bashkir State Medical University Ufa Russia
Department of Clinical Oncology University College London Hospitals NHS Foundation Trust London UK
Department of Histopathology University College London Hospitals NHS Foundation Trust London UK
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Pathology Medical University of Vienna Vienna Austria
Department of Urological Surgery Duke University Medical Center Durham NC USA
Department of Urology Atrium Health Wake Forest Baptist Winston Salem NC USA
Department of Urology Clinica Universidad de Navarra Madrid Spain
Department of Urology David Geffen School of Medicine at UCLA Los Angeles CA USA
Department of Urology Grenoble Alpes University Hospital Université Grenoble Alpes Grenoble France
Department of Urology Hospital Louis Pasteur Chartres France
Department of Urology Institut Mutualiste Montsouris Paris France
Department of Urology Instituto Valenciano de Oncologia Valencia Spain
Department of Urology Lenox Hill Hospital New York NY USA
Department of Urology St Vincent's Prostate Cancer Centre Sydney NSW Australia
Department of Urology University of Washington School of Medicine Seattle WA USA
Division of Surgery and Interventional Science University College London UK
Division of Urology Department of Surgery McGill University Montreal QC Canada
Garvan Institute of Medical Research Sydney NSW Australia
International School of Medicine Istanbul Medipol University Istanbul Turkey
Martini Klinik Prostate Cancer Center University Hospital Hamburg Eppendorf Hamburg Germany
Radiation Oncology Department Institut Gustave Roussy Villejuif France
St Vincent's Clinical School UNSW Sydney Sydney NSW Australia
Citace poskytuje Crossref.org
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