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Tuberculosis after hematopoietic cell transplantation: retrospective study on behalf of the Infectious Diseases Working Party of the EBMT
J. Drozd-Sokołowska, G. Tridello, I. Verheggen, M. Karakukcu, N. Ben Abdeljelil, A. Colita, M. Aljurf, N. Kröger, G. Ozturk, J. Passweg, M. Gambella, M. Popova, L. López Corral, A. Tanase, A. Piekarska, M. Al Zahrani, MC. Ar, G. Basak, AEC....
Language English Country England, Great Britain
Document type Journal Article, Multicenter Study
- MeSH
- Child MeSH
- Adult MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Child, Preschool MeSH
- Retrospective Studies MeSH
- Hematopoietic Stem Cell Transplantation * adverse effects methods MeSH
- Tuberculosis * etiology mortality drug therapy MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
Tuberculosis (TB) is rare following hematopoietic cell transplantation (HCT). In this multinational retrospective study, we report the frequency, characteristics, and outcome of TB following HCT performed during 2000-2019. Fifty-two patients (35 (67%) males, 15 (29%) children) from 24 centers developed TB following allogeneic (n = 47) or autologous (n = 5) HCT; with the relative frequency of 0.21% and 0.025%, respectively. Forty (77%) were bacteriologically, 12 (23%) clinically confirmed. The median time from HCT to TB was 135 (range, 16-3225) days. Eighteen (35%) patients with extrapulmonary TB (mainly involving lymph nodes and liver/spleen) were significantly younger, developed TB shorter after HCT, more often had inherited underlying disease, and received immunosuppressive therapy at TB diagnosis as compared to pulmonary TB. Five (22%) of 23 patients with drug-susceptibility testing performed, were resistant to at least one anti-TB drug. Treatment success was achieved in 38/50 (76%) of treated patients. One-year overall survival reached 75.7% and the 1-year cumulative incidence of TB-associated death was 18.1%. Concluding, TB is a rare, albeit severe complication, which can develop any time after HCT, frequently involves extrapulmonary sites, and results in high mortality rates. High proportion of drug-resistant TB warrants routine susceptibility testing.
Acibadem Saglik Hizm ve Tic A S Istanbul Turkey
Adnan Menderes University Med Faculty Aydin Turkey
Central Clinical Hospital Medical University of Warsaw Warsaw Poland
Central Hospital of Southern Pest Budapest Hungary
Centre Hospitalier Lyon Sud Lyon France
Centre National de Greffe de Moelle Tunis Tunisia
Charles University Hospital Pilsen Czech Republic
Collegium Medicum UMK University Hospital Bydgoszcz Poland
Department of Haematology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield United Kingdom
Department of Hematology Poznan University of Medical Sciences Poznan Poland
EBMT Leiden Statistical Unit Leiden the Netherlands
EBMT Leiden Study Unit Leiden The Netherlands
Erasmus MC Cancer Institute Rotterdam Netherlands
Erciyes University Faculty of Medicine Kayseri Turkey
Fundeni Clinical Institute Bucharest Romania
Glasgow Royal Infirmary Glasgow United Kingdom
Hadassah Medical Center Jerusalem Israel
HELIOS Klinikum Berlin Buch Berlin Germany
Hospital Clínico Salamanca Spain
Hospital de la Princesa Madrid Spain
IRCCS Institute G Gaslini Genova Italy
IRCCS Ospedale Policlinico San Martino Genova Italy
Istanbul University Cerrahpasa Istanbul Turkey
Karolinska University Hospital Stockholm Sweden
King Abdulaziz Medical City Riyadh Saudi Arabia
King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia
Pediatric Infectious Diseases Faculty of Medicine Hebrew University of Jerusalem
RM Gorbacheva Research Institute Pavlov University Petersburg Russian Federation
San Matteo Pavia Transplant Programme Pavia Italy
Sheffield Childrens NHS Foundation Trust Sheffield United Kingdom
University Clinical Centre in Gdansk Gdansk Poland
University Hospital | Uppsala Uppsala Sweden
University Hospital Basel Basel Switzerland
University Hospital Eppendorf Hamburg Germany
University of Genoa and IRCCS Ospedale Policlinico San Martino Genova Italy
References provided by Crossref.org
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