The protective effect of oestrogens is probably caused also by the active inhibition of the inflammatory reaction of the acute phase and release of inflammatory cytokines type IL-1beta or TNF-alpha by this hormone. We formulated this hypothesis because we recorded a drop of the protein of the acute stage, orosomucoid, in relation to the rising oestrogen level during pregnancy (r = -0.511, p < 0.0001). It ensues also from the finding of a lower level of cytoadhesive molecules of sE-selectins in a group of 66 pregnant women (sE-sel.: 32.95 ± 12.5 ng/ml) with a higher level of 17-beta estradiol (17-beta E2:9.34 ± 7.8 nmolA), as compared with the sE-selectin level in a group of 14 women after ovariectomy (sE-sel.: 43.97 ± 8.174 ng/ml, p < 0.016) who lacked oestrogen (17-beta E2 0.14 ± 0.13 nmolA) and in a group of pregnant women (n 19) in the first trimester with level of 17-beta E2: 1.89 ± 0.711 nmolA where the sE-selectin concentrations at the onset pregnancy was higher (sE-sel.: 35.59 ± 9.5 ng/ml) than in a group of pregnant women (n 38) during the second and third trimester (sE-sel.: 30.58 ± 13.3 ng/ml, p < 0.05) with 17-beta E2 concentration 11.96 ± 7.18 ng/ml. The finding of lower sE - selectin levels which is a sign that the endothelium is not exposed to the action of inflammatory cytokines IL-1 or TNF may thus be associated with the active „control" of thrombophilia in pregnancy. When during pregnancy in conjunction with oestrogen levels changes in the lipid concentration were investigated a compensating mechanism could be observed. Hypercholesterolaemia and hypertriglyceridaetíiia in pregnant women was associated with a rise of oestrogen levels as well as of „cardioprotective" HDL-cholesterol (the HDL level was during the first trimester 1.31 ± 0.26 nmol/l, in the second and third trimester 1.69 ± 0.48 nmol/l, p < 0.0167).

VFN Oddělení klinické hematologie Praha

Changes in concentrations of cytoadhesive molecules, acute stage proteins, lipids and haemostasis in relation to the endogenous oestrogen level during pregnancy and after ovariectomy

Změny v koncentracích cytoadhezivních molekul, proteinů akutní fáze, lipidů a hemostázy v závislosti na hladině endogenního estrogenu v těhotenství a po ovarektomii = Changes in concentrations of cytoadhesive molecules, acute stage proteins, lipids and haemostasis in relation to the endogenous oestrogen level during pregnancy and after ovariectomy /

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