The authors describe the case of a 12-year-old girl with manifestations of Raynaud's syndrome, later with stiffening of the skin on the hands, feet, face and a livid to whitish coloration of the skin, pain in muscles and joints, restricted mobility. Based on the clinical picture and development of the disease, examination of the milieu intérieur, functional examination of organs and immunohistological examination the authors established the diagnosis of Sharp's syndrome. The immunohistological examination of the skin confirmed the presence of immunocomplexes with IgG antibodies of a granular type in the area of the junction and immunocomplexes with IgG, IgM antibodies, the C3 complement component and fibrin in the vascular walls of the corium. For complete diagnosis they used positive ANA, the titre of which was high while there was a markedly intense fluorescence of nuclei of epidermal cells and positive anti-ENA antibodies.

UPJŠ LF FNsP Kožná klinika Košice

Immunohistological diagnosis of Sharp's syndrome

Imunohistologická diagnostika Sharpovho syndrómu = Immunohistological diagnosis of Sharp's syndrome /

Immunohistological diagnosis of Sharp's syndrome /

Lit: 21

Souhrn en