Two types of epileptic cortical after-discharges evoked by the stimulation of the hippocampus and thalamic nuclei in rats
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
550686
Knihovny.cz E-resources
- MeSH
- Electric Stimulation MeSH
- Electroencephalography * MeSH
- Electrophysiology MeSH
- Epilepsy physiopathology MeSH
- Evoked Potentials MeSH
- Hippocampus physiopathology MeSH
- Thalamic Nuclei physiopathology MeSH
- Rats MeSH
- Somatosensory Cortex physiopathology MeSH
- Thalamus physiopathology MeSH
- Occipital Lobe physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Rhythmic cortical phenomena were evoked by stimulation of hippocampus and/or thalamus in rats. Electrical stimulation of thalamic nuclei (nc. ventralis dorsomedialis VDM and nc. lateralis anterior--LA) by single pulses elicited rhythmic after-discharge ("spindle") as a late component of the cortical response, whereas identical stimulation of hippocampus did not trigger such an activity. Rhythmic stimulation of thalamic nuclei elicited cortical incremental responses more often than stimulation of hippocampus. Epileptic self-sustained after-discharges (AD) occurred after the endo of rhythmic stimulation in 66% of hippocampal stimulations, in 35% of VDM stimulations and in 30% of LA stimulations. AD evoked by stimulation of the hippocampus (long duration discharges of slow serrated waves) differed characteristically from AD following stimulation of the VMD (short duration spike and wave complexes). Stimulation of the LA in half of the cases led to the "hippocampal" pattern of serrated wave after-discharges, in the remaining cases spike-and-wave complexes or a combined AD pattern was recorded.