Effects of clonazepam on picrotoxin-induced convulsions
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
1286082
Knihovny.cz E-resources
- MeSH
- Anticonvulsants pharmacology MeSH
- Epilepsy chemically induced physiopathology prevention & control MeSH
- Injections, Intraperitoneal MeSH
- Clonazepam pharmacology MeSH
- Rats MeSH
- Picrotoxin * MeSH
- Rats, Wistar MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced physiopathology prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anticonvulsants MeSH
- Clonazepam MeSH
- Picrotoxin * MeSH
The convulsant effects of four doses of picrotoxin (PX)-2, 3, 4, and 6 mg/kg s.c.-were evaluated in the first part of the study. The 4-mg/kg dose, which elicited minimal seizures in all animals, generalized tonic-clonic (major) seizures in 75% of rats and fatal outcome in 69% of rats, was chosen for the second part, i.e. for testing the anticonvulsant action of clonazepam (Rivotril Roche, 0.1 or 1 mg/kg i.p.). Clonazepam exhibited a dose-dependent action against PX-induced seizures, being more efficient against major than against minimal seizures.