Picrotoxin-induced tonic-clonic seizures and lethality are decreased by MK-801 in developing rats
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
1409814
DOI
10.1016/0091-3057(92)90670-b
PII: 0091-3057(92)90670-B
Knihovny.cz E-resources
- MeSH
- Ataxia chemically induced physiopathology MeSH
- Behavior, Animal drug effects MeSH
- Dizocilpine Maleate pharmacology MeSH
- Epilepsy, Tonic-Clonic chemically induced prevention & control MeSH
- Rats MeSH
- Picrotoxin * antagonists & inhibitors toxicity MeSH
- Rats, Wistar MeSH
- Aging physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dizocilpine Maleate MeSH
- Picrotoxin * MeSH
The action of MK-801 (NMDA antagonist; 0.1 and 0.5 mg/kg, IP) was tested against picrotoxin-induced seizures (3-6 mg/kg, IP) in rats aged 7, 12, 18, 25, and 90 days. We found MK-801 only inconsistently affected clonic seizures in 12- and 25-day-old rats, whereas tonic-clonic seizures were suppressed or delayed in almost all age groups. In addition, the lethality of picrotoxin was diminished by the higher dose of MK-801 in all age groups. The results suggest: a) different generators for both seizure patterns (clonic and tonic-clonic), b) an involvement of NMDA receptors in the genesis of tonic-clonic seizure pattern, and c) an interaction of MK-801 with GABAergic transmission throughout the entire development studied.
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