Vedlejsí úcinky amitriptylinu v závislosti na jeho plazmatických hladinách
[Side effects of amitriptyline in relation to its plasma levels]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
1505046
- MeSH
- Amitriptyline adverse effects blood therapeutic use MeSH
- Depressive Disorder blood drug therapy MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Amitriptyline MeSH
In a 21-day investigation in 15 patients with depression the authors investigated the incidence of undesirable side-effects in relation to plasma amitriptyline levels. The authors found the upper range of plasma concentrations when the patient's risk is minimal as regards serious undesirable complications. This upper limit is 350 micrograms/l; as compared with previous work, they consider amitriptyline levels from 150 to 350 350 micrograms/l safe and therapeutically effective. The authors consider investigation of plasma levels indicated in risk patients and in patients with an inadequate response to treatment.
