MaTu is an agent, believed to be derived from a human mammary carcinoma, which displayed several extraordinary properties. These were: RIP and PAGE revealed in MaTu-infected cells only a single protein band of Mr 58 k, the gp 58. This gp 58 was immunoprecipitated by antibodies present in some human sera as well as in some sera of rabbits, sheep, and cattle. MaTu had an extremely restricted host range: it was transmissible only to HeLa cells, but not to human embryo fibroblasts, to three human tumour cell lines (T 47 D, T 24, and HMB 2) or to monkey Vero and rabbit SIRC cells. A retrovirus with a broad host range, used as a helper (X-MLV) enabled the transmission of MaTu to human fibroblasts, but not to Vero or SIRC, which are also permissive for X-MLV. These observations, together with our previous reports, support the view that MaTu might either be a novel type of defective virus, or even a non-viral autonomous genetic element.

Institute of Virology Slovak Academy of Sciences Bratislava Czechoslovakia

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J Gen Virol. 1974 Aug;24(2):327-37 PubMed

Nature. 1970 Aug 15;227(5259):680-5 PubMed

Arch Virol. 1976;50(1-2):1-15 PubMed

Arch Geschwulstforsch. 1974;44(1):1-10 PubMed

J Gen Virol. 1982 Nov;63 (Pt 1):15-24 PubMed

Int J Cancer. 1973 May;11(3):765-73 PubMed

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1617-21 PubMed

J Immunol. 1975 Dec;115(6):1617-24 PubMed

Virology. 1974 Jan;57(1):271-8 PubMed

Virology. 1977 Oct 1;82(1):221-31 PubMed

Nat New Biol. 1972 Nov 22;240(99):124-5 PubMed

Int J Cancer. 1976 Jun 15;17(6):780-4 PubMed

Neoplasma. 1988;35(6):665-81 PubMed

J Natl Cancer Inst. 1979 Jan;62(1):95-101 PubMed

Eur J Cancer. 1979 May;15(5):659-70 PubMed