Hydroxyurea as a suppressor of the radioprotective effect of dextran sulfate on bone marrow hemopoietic stem cells in mice
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu časopisecké články
PubMed
1692979
Knihovny.cz E-zdroje
- MeSH
- dextrany farmakologie MeSH
- hematopoetické kmenové buňky účinky léků účinky záření MeSH
- hydroxymočovina farmakologie MeSH
- míra přežití MeSH
- myši inbrední C57BL MeSH
- myši inbrední CBA MeSH
- myši MeSH
- radioprotektivní látky farmakologie MeSH
- síran dextranu MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dextrany MeSH
- hydroxymočovina MeSH
- radioprotektivní látky MeSH
- síran dextranu MeSH
The changes in hemopoiesis of mice following intraperitoneal administration of dextran sulfate (DS) 24 h before irradiation, as well as the effect of injecting them with hydroxyurea (HU), were analyzed. DS increased the proliferation activity and number of hemopoietic stem cells (CFUs) in the bone marrow. The content of CFUs in the bone marrow and the number of endogenous spleen colonies (ESC) of hemopoietic tissue were higher after irradiation in mice treated with DS than in control groups. The survival rate following a lethal radiation dose was also higher. Injection with HU decreased the number of CFUs in animals injected with DS to the level of controls and suppressed its radioprotective effect.
