The influence of mechanical injury on the metabolic activity of transplanted cerebral cortex
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
1718412
Knihovny.cz E-zdroje
- MeSH
- acetylcholin metabolismus MeSH
- adenosintrifosfát metabolismus MeSH
- aminokyseliny metabolismus MeSH
- DNA metabolismus MeSH
- fosfokreatin metabolismus MeSH
- glukosa metabolismus MeSH
- krysa rodu Rattus MeSH
- laktáty metabolismus MeSH
- mozková kůra embryologie zranění metabolismus transplantace MeSH
- RNA metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholin MeSH
- adenosintrifosfát MeSH
- aminokyseliny MeSH
- DNA MeSH
- fosfokreatin MeSH
- glukosa MeSH
- laktáty MeSH
- RNA MeSH
The authors studied the metabolic activity of rat embryonic cerebral cortex grafts (ED 15-16) implanted into rat brains immediately (TR0) and 14 days (TR14) after cavity formation. Over a period of two months, the ATP, lactate and glucose concentration in TR0 transplants remained at the same level as observed in the intact cortex, whereas in TR14 transplants the ATP and glucose concentration fell significantly and the lactate concentration rose. The DNA concentration rose in both types of transplants, but the increase was more pronounced in TR0 grafts. Choline acetyltransferase activity (a neuron marker) fell significantly in both cases, but the decrease was greater in TR14 transplants. The results indicate that grafts implanted into the brain immediately after cavities had been formed have better metabolic activity and are capable of longer survival than grafts implanted 14 days after cavitation.
