Antigen recognition and IL-2 receptor gene expression as evidence against clonal deletion in mice with neonatally induced transplantation tolerance
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
1739987
DOI
10.1016/0008-8749(92)90192-r
PII: 0008-8749(92)90192-R
Knihovny.cz E-zdroje
- MeSH
- biologické modely MeSH
- buňky kostní dřeně MeSH
- exprese genu MeSH
- histokompatibilní antigeny imunologie MeSH
- imunologická tolerance genetika MeSH
- messenger RNA biosyntéza MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- novorozená zvířata MeSH
- receptory interleukinu-2 genetika MeSH
- slezina cytologie MeSH
- transplantační imunologie genetika MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- histokompatibilní antigeny MeSH
- messenger RNA MeSH
- receptory interleukinu-2 MeSH
Neonatal transplantation tolerance was induced in B10.A mice by the injection of spleen and bone marrow cells from semiallogeneic [C57BL/10(B10) x B10.A] F1 donors. The neonatally treated mice accepted skin grafts from B10 donors. Spleen cells from tolerant animals did not respond by proliferation to tolerated B10 antigens in vitro. However, spleen cells from tolerant mice recognized specific (B10) antigens and synthesized mRNA for the inducible 55-kDa interleukin-2 receptor (IL-2R) as did cells from normal animals. Maintenance of this early phase of cell activation upon contact with tolerated antigens is direct evidence against clonal deletion as a mechanism, in this particular model of neonatally induced transplantation tolerance.
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