The presented classification is based on the modern view to the process of phagocytosis as evenements involving ligand-receptor interaction, transmission of signal through second messenger systems and activation of effector mechanisms leading to the specific cell behavior. According proposed classification, the phagocytic disorders are divided into extracellular disorders which are caused by abnormalities affecting ligands, and cellular disorders caused by pathological process affecting the phagocytic cell. These cellular disorders are subdivided into the defects of membrane receptors, the defects of enzymatic equipment and of subcellular structures. Laboratory investigation of phagocytic cells using several tests make possible to classify inborn, acquired, permanent as well as transient disorders into these groups. Examples of disorders in the each group are presented. This classification helps to clinicians make both diagnostic and therapeutic decisions.

Oddĕlení klinické imunologie 1 lékarské fakulty Univerzity Karlovy Praha