Elimination of benfluron and its metabolites in the faeces and urine of rats
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
- MeSH
- biotransformace MeSH
- feces chemie MeSH
- fluoreny farmakokinetika moč MeSH
- hmotnostní spektrometrie MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- protinádorové látky farmakokinetika moč MeSH
- spektrofotometrie infračervená MeSH
- spektrofotometrie ultrafialová MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- benzo(c)fluorene MeSH Prohlížeč
- fluoreny MeSH
- protinádorové látky MeSH
- VUFB 13468 MeSH Prohlížeč
The study of the biotransformation of the potential cytostatic benfluron has been continued. The elimination of benfluron and of nine of its metabolites whose structure had been established, mainly on the basis of the comparison of their IR, MS and NMR spectra with those of standards, was studied. After oral administration of 500 mg.kg-1 to rats, the amounts of these substances in the faeces and urine were followed up by high-performance liquid chromatography for five days. Striking qualitative and quantitative differences were observed in the elimination of benfluron and its metabolites by both routes.
Citace poskytuje Crossref.org
