Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats
Language English Country Netherlands Media print
Document type Journal Article
PubMed
1918875
DOI
10.1016/0168-8278(91)90857-8
PII: 0168-8278(91)90857-8
Knihovny.cz E-resources
- MeSH
- Amino Acids blood MeSH
- Cell Division drug effects MeSH
- DNA metabolism MeSH
- Phenylalanine blood MeSH
- Glucose administration & dosage pharmacology MeSH
- Hepatectomy MeSH
- Rats, Inbred Strains MeSH
- Infusions, Intravenous MeSH
- Liver cytology metabolism physiology MeSH
- Rats MeSH
- Liver Regeneration drug effects MeSH
- Thymidine metabolism MeSH
- Tyrosine blood MeSH
- Amino Acids, Branched-Chain administration & dosage pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Amino Acids MeSH
- DNA MeSH
- Phenylalanine MeSH
- Glucose MeSH
- Thymidine MeSH
- Tyrosine MeSH
- Amino Acids, Branched-Chain MeSH
Immediately after 70% hepatectomy, rats were infused via the jugular vein with one of the following solutions: saline, 3% or 8% glucose solution, 3% BCAA solution, 8% Nutramin (17% BCAA) or 8% Nutramin enriched with BCAA (47% BCAA). Rats were killed 18, 21, 24 and 30 h after partial hepatectomy. The course of liver regeneration was assessed from incorporation of labeled thymidine into DNA and from hepatocyte mitotic activity. After partial hepatectomy a decrease of glycemia and increase of plasma phenylalanine concentrations were observed. Glucose infusion had a pronounced inhibiting effect on the onset of liver regeneration. The decreased incorporation of labeled thymidine into DNA and the decreased hepatocyte mitotic activity in glucose-infused rats were associated with higher plasma concentrations of tyrosine and phenylalanine. Parenteral administration of 3% BCAA solution and 8% Nutramin enriched with BCAA had a favourable effect on the onset of liver regeneration after partial hepatectomy compared with glucose- and Nutramin-infused groups. In BCAA-infused rats elevated levels of BCAA and decreased concentrations of tyrosine and phenylalanine were noted.
References provided by Crossref.org
Plasma amino acids in four models of experimental liver injury in rats
