Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
1918875
DOI
10.1016/0168-8278(91)90857-8
PII: 0168-8278(91)90857-8
Knihovny.cz E-zdroje
- MeSH
- aminokyseliny krev MeSH
- buněčné dělení účinky léků MeSH
- DNA metabolismus MeSH
- fenylalanin krev MeSH
- glukosa aplikace a dávkování farmakologie MeSH
- hepatektomie MeSH
- inbrední kmeny potkanů MeSH
- intravenózní infuze MeSH
- játra cytologie metabolismus fyziologie MeSH
- krysa rodu Rattus MeSH
- regenerace jater účinky léků MeSH
- thymidin metabolismus MeSH
- tyrosin krev MeSH
- větvené aminokyseliny aplikace a dávkování farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aminokyseliny MeSH
- DNA MeSH
- fenylalanin MeSH
- glukosa MeSH
- thymidin MeSH
- tyrosin MeSH
- větvené aminokyseliny MeSH
Immediately after 70% hepatectomy, rats were infused via the jugular vein with one of the following solutions: saline, 3% or 8% glucose solution, 3% BCAA solution, 8% Nutramin (17% BCAA) or 8% Nutramin enriched with BCAA (47% BCAA). Rats were killed 18, 21, 24 and 30 h after partial hepatectomy. The course of liver regeneration was assessed from incorporation of labeled thymidine into DNA and from hepatocyte mitotic activity. After partial hepatectomy a decrease of glycemia and increase of plasma phenylalanine concentrations were observed. Glucose infusion had a pronounced inhibiting effect on the onset of liver regeneration. The decreased incorporation of labeled thymidine into DNA and the decreased hepatocyte mitotic activity in glucose-infused rats were associated with higher plasma concentrations of tyrosine and phenylalanine. Parenteral administration of 3% BCAA solution and 8% Nutramin enriched with BCAA had a favourable effect on the onset of liver regeneration after partial hepatectomy compared with glucose- and Nutramin-infused groups. In BCAA-infused rats elevated levels of BCAA and decreased concentrations of tyrosine and phenylalanine were noted.
Citace poskytuje Crossref.org
Plasma amino acids in four models of experimental liver injury in rats
