The effect of a variable initial value is examined in Stein's stochastic neuronal model with synaptic reversal potentials under the conditions of a constant threshold and a constant input. The moments of the interspike interval distribution are presented as the functions of the initial depolarization which ranges from inhibitory reversal potential to the threshold potential. Normal, exponential and transformed Gamma distributions are tested for the initial value of depolarization. The coefficient of variation is shown to be greater than one when the initial depolarization is sufficiently above the resting level. An interpretation of this result in the terms of spatial facilitation is offered. The effect of a random initial value is found to be most pronounced for the neurons depolarized to a near threshold level.

Institute of Physiology Czechoslovak Academy of Sciences Prague

See more in PubMed

Biophys J. 1978 Mar;21(3):289-90 PubMed

Biophys J. 1964 Jan;4:41-68 PubMed

Biophys J. 1967 Jan;7(1):37-68 PubMed

Biol Cybern. 1977 Oct 14;27(4):199-213 PubMed

Biol Cybern. 1979 Nov;35(1):1-9 PubMed

Biol Cybern. 1987;56(1):19-26 PubMed

J Theor Biol. 1978 Mar 20;71(2):167-83 PubMed

J Theor Biol. 1983 Nov 21;105(2):345-68 PubMed

J Neurophysiol. 1983 May;49(5):1182-98 PubMed

Biophys J. 1965 Mar;5:173-94 PubMed

Biophys J. 1964 Sep;4(5):417-9 PubMed

J Physiol. 1952 Aug;117(4):431-60 PubMed

J Theor Biol. 1979 Mar 7;77(1):65-81 PubMed

Biol Cybern. 1988;59(3):201-15 PubMed

Biol Cybern. 1986;54(1):41-51 PubMed

Biol Cybern. 1988;58(6):387-404 PubMed

Math Biosci. 1989 Apr;93(2):191-215 PubMed

Biol Cybern. 1984;51(2):123-8 PubMed

Biol Cybern. 1987;55(5):299-311 PubMed

On the comparison of Feller and Ornstein-Uhlenbeck models for neural activity