Different effect of hyperthermia and heat shock on the action of quinolone drugs versus some mutagens against chloroplasts of Euglena gracilis
Language English Country Netherlands Media print
Document type Journal Article
- MeSH
- Anti-Bacterial Agents toxicity MeSH
- Quinolines toxicity MeSH
- Chloroplasts drug effects MeSH
- Euglena gracilis MeSH
- Furylfuramide toxicity MeSH
- Mutagens pharmacology MeSH
- Nitrosoguanidines toxicity MeSH
- Hot Temperature adverse effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Quinolines MeSH
- Furylfuramide MeSH
- Mutagens MeSH
- Nitrosoguanidines MeSH
Hyperthermia (37 degrees C permanently) and heat shock (42 degrees C for 10 min, and then 27 degrees C) retarded the elimination of chloroplasts from the flagellate Euglena gracilis induced by quinolone antibacterial chemotherapeutics (OA, NA, Cnx, Ofx, Cpfx, Enx, Nfx) in comparison with their action at 27 degrees C. In the case of OA, NA, and Cnx those hyperthermic conditions completely blocked their action against chloroplasts. On the other hand, both temperature regimes accelerated the antichloroplast activity of the mutagens/carcinogens nitrosoguanidine and furylfuramide.
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