Dose and time dependence of chromosomal aberration yields of bone marrow cells in male Chinese hamsters after a single i.p. injection of aflatoxin B1
Language English Country Netherlands Media print
Document type Journal Article
PubMed
2114541
DOI
10.1016/0165-7992(90)90127-6
PII: 0165-7992(90)90127-6
Knihovny.cz E-resources
- MeSH
- Aflatoxin B1 MeSH
- Aflatoxins administration & dosage toxicity MeSH
- Chromosome Aberrations * MeSH
- Cricetulus MeSH
- Injections, Intraperitoneal MeSH
- Kinetics MeSH
- Bone Marrow drug effects ultrastructure MeSH
- Cricetinae MeSH
- Mutagens * MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Aflatoxin B1 MeSH
- Aflatoxins MeSH
- Mutagens * MeSH
The frequency of chromosomal aberrations in bone marrow cells, after a single i.p. aflatoxin B1 (AFB1) dose, was examined in male Chinese hamsters (Cricetulus griseus). There was a significant increase in aberrant cells within 5 days of administration of a dose of 0.1 micrograms-5 mg AFB1/kg, and on the 36th day. After a single dose of 5 mg AFB1/kg the enhanced frequency of aberrant cells was monitored up to day 104 with no sign of a decrease to control level. The results indicate that the minimum mutagenic effect of an AFB1 dose in this system is 0.1 micrograms/kg. Attention is drawn to the long-term presence of chromosomal aberrations even after a single i.p. exposure to AFB1.
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