The labilizing and stabilizing effect of physostigmine on CNS
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2151099
Knihovny.cz E-resources
- MeSH
- Dopamine metabolism MeSH
- Physostigmine pharmacology MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Brain Stem drug effects metabolism MeSH
- Norepinephrine metabolism MeSH
- Serotonin metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Dopamine MeSH
- Physostigmine MeSH
- Norepinephrine MeSH
- Serotonin MeSH
The authors observed biphasic changes of dopamine, norepinephrine and serotonin in the rat brain stem after a single application of physostigmine (1 mg/kg of body weight). The results confirm the hypothesis of "labilization and stabilization" of membranes.