Arachidonate has a positive effect on the electrogenic sodium-potassium pump in the mouse diaphragm
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2440070
Knihovny.cz E-resources
- MeSH
- Diaphragm drug effects metabolism MeSH
- Potassium metabolism MeSH
- Muscle, Smooth drug effects metabolism MeSH
- Ion Channels drug effects metabolism MeSH
- Arachidonic Acid MeSH
- Arachidonic Acids pharmacology MeSH
- Membrane Potentials drug effects MeSH
- Mice MeSH
- Sodium metabolism MeSH
- Sodium-Potassium-Exchanging ATPase metabolism MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Potassium MeSH
- Ion Channels MeSH
- Arachidonic Acid MeSH
- Arachidonic Acids MeSH
- Sodium MeSH
- Sodium-Potassium-Exchanging ATPase MeSH
Sodium arachidonate 5 X 10(-5) mol X l-1 shortened the time course of hyperpolarization caused by the electrogenic Na+-K+ pump in intact muscle fibres in the mouse diaphragm preincubated in a K+-free physiological solution. Contrary to experiments on membrane fragments, no inhibition of the ouabain-sensitive Na+-K+ ATPase was observed. It is unlikely that the arachidonate may be identical with the endogenous "ouabain-like" substance (Bidard et al. 1984).
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