The effect of indomethacin on nucleic acids in blood, hemopoietic and lymphoid tissues in continuously irradiated rats
Language English Country Slovakia Media print
Document type Journal Article
PubMed
2478902
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Radiation Dosage MeSH
- DNA analysis blood MeSH
- Rats, Inbred Strains MeSH
- Indomethacin pharmacology MeSH
- Bone Marrow drug effects metabolism radiation effects MeSH
- Rats MeSH
- Lymphoid Tissue drug effects metabolism radiation effects MeSH
- Radiation-Protective Agents * MeSH
- RNA analysis blood MeSH
- Spectrophotometry MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- DNA MeSH
- Indomethacin MeSH
- Radiation-Protective Agents * MeSH
- RNA MeSH
The effect of indomethacin--a nonsteroid antiinflammatory drug with potential antitumor activity--on the development of radiation-induced changes was followed in blood, bone marrow, spleen, thymus and testes of rats. Indomethacin administered in drinking water (0.7-1.0 mg/kg per day) during a continuous 7-day irradiation with gamma rays (dose rate of 2.055 Gy/day, total accumulated dose of 14.385 Gy) caused a higher and more rapid incorporation of 3H-thymidine into blood DNA, and an increase in blood RNA concentration. The results suggest some stimulation of hemopoiesis recovery by indomethacin treatment in continuously irradiated rats.
Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review
