Effects of the acute and chronic administration of chlordiazepoxide on the development of spontaneous motility in chick embryos
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2528770
Knihovny.cz E-resources
- MeSH
- Bicuculline pharmacology MeSH
- Time Factors MeSH
- Chlordiazepoxide administration & dosage pharmacology MeSH
- gamma-Aminobutyric Acid pharmacology MeSH
- Chick Embryo drug effects physiology MeSH
- Pentylenetetrazole pharmacology MeSH
- Picrotoxin pharmacology MeSH
- Movement drug effects MeSH
- Strychnine pharmacology MeSH
- Animals MeSH
- Check Tag
- Chick Embryo drug effects physiology MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Bicuculline MeSH
- Chlordiazepoxide MeSH
- gamma-Aminobutyric Acid MeSH
- Pentylenetetrazole MeSH
- Picrotoxin MeSH
- Strychnine MeSH
The effects of the acute and chronic administration of chlordiazepoxide on spontaneous motility and on the reactivity of the generator of embryonic motility were studied in chick embryos from the 4th to the 19th day of incubation. 1. The acute administration of chlordiazepoxide (5 mg/kg e.w.) significantly depressed spontaneous motility from the 13th day of incubation. 2. The chronic administration of chlordiazepoxide (12.2 mg/kg e.w./24 h) from the 4th to the 8th, 12th and 16th day of incubation enhanced the reduction of the spontaneous motility of 17-day-old embryos. 3. The chronic administration of chlordiazepoxide significantly modified the activity of both activators (strychnine, metrazol, bicuculline, picrotoxin) and inhibitors (GABA, chlordiazepoxide) of the spontaneous motility of chick embryos.
