Using a simpler method for cystylaminopeptidase (oxytocinase) investigation modified by means of p-nitranilide the oxytocinase activity was examined in blood serum of 51 pregnant women with complicated pregnancy in the period of week 31-34 of gestation. Lower oxytocinase values were found in women with complicated course of pregnancy compared to those in women with physiological course of pregnancy and the same gestational age. Significantly low oxytocinase activity values were established in pregnant women with preterm uterine activity. A significant variability was found in the whole group of 51 women with complicated pregnancy as well as in individual groups.

2 gynekologicko porodnická klinika fakulty vseobecného lékarství Univerzity Karlovy Praha