Results of second trimester prenatal diagnosis of cystic fibrosis in risk families
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
2569963
Knihovny.cz E-resources
- MeSH
- Chlorides analysis MeSH
- Cystic Fibrosis diagnosis MeSH
- Adult MeSH
- Pregnancy Trimester, Second MeSH
- gamma-Glutamyltransferase analysis MeSH
- Clinical Enzyme Tests MeSH
- Infant MeSH
- Humans MeSH
- Amniotic Fluid enzymology MeSH
- Sweat analysis MeSH
- Prenatal Diagnosis * MeSH
- Risk Factors MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Chlorides MeSH
- gamma-Glutamyltransferase MeSH
Investigation of 17 children delivered after prenatal examination of amniotic fluid GGT was performed. GGT testing was carried out in the 17th-18th week of gestation. The development of children unaffected by cystic fibrosis was predicted. In all pregnancies, clinically healthy children with normal sweat chloride concentrations were delivered. Our results confirm the advantage of the examination of microvillar enzymes in amniotic fluid in the second trimester as a rather reliable method of fetal diagnosis of cystic fibrosis if it is impossible to use the molecular genetic methods in the first trimester.
