Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men
Language English Country Netherlands Media print
Document type Journal Article
PubMed
2646038
DOI
10.1016/0009-8981(89)90167-8
PII: 0009-8981(89)90167-8
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Erythrocyte Membrane analysis MeSH
- Erythrocytes metabolism MeSH
- Phospholipids blood MeSH
- Insulin metabolism MeSH
- Arachidonic Acids blood MeSH
- Linoleic Acids blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Fatty Acids blood MeSH
- Membrane Lipids blood MeSH
- Receptor, Insulin physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Phospholipids MeSH
- Insulin MeSH
- Arachidonic Acids MeSH
- Linoleic Acids MeSH
- Fatty Acids MeSH
- Membrane Lipids MeSH
- Receptor, Insulin MeSH
The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p less than 0.05) was seen. Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.
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