Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men

Jazyk angličtina Země Nizozemsko Médium print

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Perzistentní odkaz   https://www.medvik.cz/link/pmid02646038
Odkazy

PubMed 2646038
DOI 10.1016/0009-8981(89)90167-8
PII: 0009-8981(89)90167-8
Knihovny.cz E-zdroje

The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p less than 0.05) was seen. Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.

Citace poskytuje Crossref.org

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