Local adoptive transfer of delayed-type hypersensitivity to tuberculin from M. bovis (BCG) infected mice
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
2691286
Knihovny.cz E-zdroje
- MeSH
- fenotyp MeSH
- mapování chromozomů MeSH
- Mycobacterium bovis * analýza genetika MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- pasivní imunizace * MeSH
- pozdní přecitlivělost * farmakoterapie genetika MeSH
- tuberkulin škodlivé účinky MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- tuberkulin MeSH
Immunological properties of the cells mediating delayed-type hypersensitvity to tuberculin and genetic requirements of this reaction have been studied by the method of local adoptive transfer. Peritoneal cells from BCG-immunized mice transferred the reaction into unprimed recipients without any genetic restriction. In contrast, nonadherent peritoneal cells transferred the reaction only in H-2-compatible donor-recipient strain combinations. The use of H-2 recombinant strains has shown that delayed-type hypersensitivity to tuberculin in mice is restricted by the I-A locus. Monoclonal antibody against I-Ak beta abrogated (without complement) the transfer of the reaction to CBA recipients. The phenotype of nonadherent cells, transferring the reaction has been shown to be Thy-1+, Lyt-1+, 2-, L3T4+.
