Comparative investigation of PMN leucocyte antimicrobial potential in animals of different species susceptibility to the plague agent
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
2824603
Knihovny.cz E-zdroje
- MeSH
- baktericidní aktivita krve MeSH
- Columbidae MeSH
- druhová specificita MeSH
- fagocytóza MeSH
- hlodavci MeSH
- kationické antimikrobiální peptidy MeSH
- králíci MeSH
- krevní proteiny analýza MeSH
- lidé MeSH
- membránové proteiny * MeSH
- mor imunologie MeSH
- náchylnost k nemoci MeSH
- neutrofily enzymologie metabolismus MeSH
- ovce MeSH
- peroxidasa metabolismus MeSH
- přirozená imunita MeSH
- psi MeSH
- spotřeba kyslíku * MeSH
- Yersinia pestis imunologie MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- lidé MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- bactericidal permeability increasing protein MeSH Prohlížeč
- kationické antimikrobiální peptidy MeSH
- krevní proteiny MeSH
- membránové proteiny * MeSH
- peroxidasa MeSH
The present work was aimed at a comparative study of oxygen-dependent metabolism (OM) and myeloperoxidase (MPO) activities as well as the content of bactericidal cationic proteins (BCP) in polymorphonuclear leucocytes (PMNL) from mammals and birds with different susceptibility to plague (mice, guinea pigs, rats, great and miday gerbils, rabbits, dogs, pigeons and man). The experimental finding of an association between infectious susceptibility and functioning of the major PMNL bactericidal systems (OM activity and BCP content) indicates that the magnitude of antimicrobial potential of professional phagocytes is a factor determining species susceptibility to plague. The intermediate and high levels of MPO activity detected in all the species studied except in pigeons suggest involvement of the MPO-H2O2-halide cytocidal system of PMNL in destroying Y. pestis.
