Irritation effects of residual products derived from p(HEMA) gels. II. Compounds extracted from hydrogels
Language English Country Netherlands Media print
Document type Journal Article
PubMed
3214663
DOI
10.1016/0142-9612(88)90036-1
PII: 0142-9612(88)90036-1
Knihovny.cz E-resources
- MeSH
- Biocompatible Materials * MeSH
- Irritants * MeSH
- Exudates and Transudates analysis MeSH
- Fibrin analysis MeSH
- Rats, Inbred Strains MeSH
- Blood Proteins metabolism MeSH
- Rats MeSH
- Skin drug effects pathology MeSH
- Polymethacrylic Acids toxicity MeSH
- Polyhydroxyethyl Methacrylate toxicity MeSH
- Prostheses and Implants MeSH
- Indium Radioisotopes MeSH
- Inflammation MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biocompatible Materials * MeSH
- Irritants * MeSH
- Fibrin MeSH
- Blood Proteins MeSH
- Polymethacrylic Acids MeSH
- Polyhydroxyethyl Methacrylate MeSH
- Indium Radioisotopes MeSH
Samples of poly(2-hydroxyethyl methacrylate) p(HEMA) hydrogels were prepared using three different polymerization initiators. The gels were washed in water under standard conditions. The extracts were then examined for intradermal irritation in rats using a radioactive indicator (113mIn). The irritation effects were dependent on the concentrations of the irritating substances and also on the gel type. Solid discs made of the gels, washed to varying degrees of purity, were also implanted into rats. Tissue irritation, as well as some other biological responses, were followed in situ using the radioindicator and common histological techniques. The irritation effects were very mild (even with the unextracted gel material). A possible explanation for the events taking place at the site of implantation is presented.
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