Generation of LAK cells depends on the age of LAK cell precursor donors
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
3260565
Knihovny.cz E-zdroje
- MeSH
- buněčné linie MeSH
- buňky NK imunologie MeSH
- cytotoxicita imunologická * MeSH
- interleukin-2 farmakologie MeSH
- myši MeSH
- rekombinantní proteiny farmakologie MeSH
- stárnutí * MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- interleukin-2 MeSH
- rekombinantní proteiny MeSH
Age-related changes in generation of lymphokine-activated killer cells were examined in the experimental system of B10 murine effector cells activated with human recombinant interleukin 2 that were allowed to react with a panel of murine and human target cell lines. The percentage of specific 51Cr release displayed by the LAK cells derived from 6- and 12-month-old donors was consistently lower than that displayed by the 2-month-old mice. However, even the LAK cells from 12-month-old mice still showed a significant cytolytic activity.
