HLA in den Karzinomen des Waldeyerschen Rachenringes
[HLA in cancers of Waldeyer's pharyngeal ring]
Language German Country Germany Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
3262607
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Gene Frequency MeSH
- HLA Antigens genetics MeSH
- HLA-B Antigens genetics MeSH
- HLA-DR Antigens genetics MeSH
- HLA-DR4 Antigen MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosome Mapping MeSH
- Adolescent MeSH
- Nasopharyngeal Neoplasms genetics MeSH
- Risk Factors MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- HLA Antigens MeSH
- HLA-B Antigens MeSH
- HLA-B17 antigen MeSH Browser
- HLA-DR Antigens MeSH
- HLA-DR4 Antigen MeSH
HLA antigens were investigated in 129 patients with various types of carcinomas of Waldeyer's ring; most of them were undifferentiated carcinomas. Significant relations were demonstrated to the antigens of the HLA system particularly in locus B (B17) and DR (DR4). Differences in the frequency of other antigens compared with a control group were not statistically significant. The presence of HLA antigens serves as a useful auxiliary clinical marker which does not change in the individual patient. It characterises the patient immunogenetically and it may also serve as guidance for differential diagnosis in the initial tumour stages. At this stage, diagnosis may be difficult with all known methods, particularly of occult head and neck tumours.
