Activation of carcinogens by peroxidase. Horseradish peroxidase-mediated formation of benzenediazonium ion from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) and its binding to DNA
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
PubMed
3378630
DOI
10.1016/0014-5793(88)80776-2
PII: 0014-5793(88)80776-2
Knihovny.cz E-zdroje
- MeSH
- diazoniové sloučeniny metabolismus MeSH
- DNA metabolismus MeSH
- edaravon MeSH
- fenazon analogy a deriváty farmakologie MeSH
- karcinogeny MeSH
- křenová peroxidasa metabolismus MeSH
- naftoly metabolismus MeSH
- oxidace-redukce MeSH
- peroxid vodíku MeSH
- peroxidasy metabolismus MeSH
- skot MeSH
- spektrofotometrie MeSH
- zvířata MeSH
- Check Tag
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 1-phenylazo-2-naphthol MeSH Prohlížeč
- benzenediazonium MeSH Prohlížeč
- diazoniové sloučeniny MeSH
- DNA MeSH
- edaravon MeSH
- fenazon MeSH
- karcinogeny MeSH
- křenová peroxidasa MeSH
- naftoly MeSH
- peroxid vodíku MeSH
- peroxidasy MeSH
Horseradish peroxidase in the presence of hydrogen peroxide (HRP/H2O2) oxidizes a carcinogenic non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) to the ultimate carcinogen, which binds to calf thymus DNA. The principal product of Sudan I oxidation by the HRP/H2O2 system is the benzenediazonium ion. Minor products are hydroxy derivatives of Sudan I, in which the aromatic rings are hydroxylated. The principal oxidative product (the benzenediazonium ion) is responsible for the carcinogenicity of Sudan I, because this ion, formed from this azo dye, binds to DNA.
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