Irritation effects of residual products derived from poly(2-hydroxyethyl methacrylate) gels. I. Testing of some model compounds
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
3408801
DOI
10.1016/0142-9612(88)90097-x
PII: 0142-9612(88)90097-X
Knihovny.cz E-zdroje
- MeSH
- dráždivé látky * MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- kůže účinky léků patologie MeSH
- kyseliny polymethakrylové * toxicita MeSH
- polyhydroxyethylmethakrylát analogy a deriváty toxicita MeSH
- radioizotopy india MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dráždivé látky * MeSH
- kyseliny polymethakrylové * MeSH
- polyhydroxyethylmethakrylát MeSH
- radioizotopy india MeSH
2-Hydroxyethyl methacrylate (HEMA) monomer and sodium benzoate, diluted with saline in the range 0-20%, were tested for intradermal irritation in rats. Radioactive indicator (113mIn) was used to quantify this biological response. At low concentrations (up to 1%) only a little irritation was recorded, while at higher levels (5% or more) a significant adverse reaction developed. The degree of irritation was dose dependent. In the concentration range 0-10%, the response was exponential. Model decomposition products derived from three different polymerization initiators were also tested. How the results obtained with the model irritants relate to real polymerization systems is discussed.
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