Activation of killer cells from blood of urinary bladder carcinoma patients by short-term treatment with recombinant interleukin 2
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
3488923
Knihovny.cz E-zdroje
- MeSH
- aktivace lymfocytů MeSH
- buněčná cytotoxicita závislá na protilátkách MeSH
- buňky NK imunologie MeSH
- cytotoxicita imunologická MeSH
- imunoterapie MeSH
- interleukin-2 imunologie MeSH
- lidé MeSH
- monoklonální protilátky MeSH
- nádory močového měchýře imunologie terapie MeSH
- techniky in vitro MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- interleukin-2 MeSH
- monoklonální protilátky MeSH
Highly purified recombinant human interleukin 2 induced cytotoxicity of lymphocytes from urinary bladder carcinoma patients and from control healthy donors when added during an 18-h 51Cr microcytotoxicity assay against bladder carcinoma (T24) target cells. Similar levels of killer cell activation were detected in mononuclear cell preparations from bladder carcinoma patients and control healthy donors; hence, no defect in the responsiveness of bladder carcinoma patients' lymphocytes to interleukin 2 could be observed. The effect of the recombinant interleukin 2 was dose-dependent. Addition of monoclonal antibody 7E9 directed against cell-type restricted antigen associated with the T24 target cells and capable of inducing antibody-dependent cellular cytotoxicity could not increase the cytotoxicity-inducing effects of interleukin 2.
