Preparation and biological activity of 5,6-dihydro-5-azapyrimidine nucleosides
Nucleic acids symposium series.
1987 ;
(18) :
57-60.
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article
Persistent link
https://www.medvik.cz/link/pmid03697151
PubMed
3697151
Knihovny.cz E-resources
- MeSH
- Leukemia L1210 drug therapy MeSH
- Mice MeSH
- Antineoplastic Agents chemical synthesis MeSH
- Purine Nucleosides chemical synthesis therapeutic use MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Antineoplastic Agents MeSH
- Purine Nucleosides MeSH
The reaction of 5-azapyrimidine nucleosides Ia-IXa with zinc powder in acetic acid afforded the respective 5,6-dihydro derivatives Ib-IXb in high yields. This procedure represents a convenient and general method for preparation of the title compounds. The effects of some dihydro-5-azapyrimidine nucleosides on the growth in vitro of L1210 mouse leukemic cells were estimated.
