A study of experimental hypersplenism
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
6745011
Knihovny.cz E-zdroje
- MeSH
- autoprotilátky analýza MeSH
- erythropoetin metabolismus MeSH
- erytrocyty imunologie MeSH
- erytropoéza účinky léků MeSH
- fagocytóza účinky léků MeSH
- hypersplenismus krev chemicky indukované MeSH
- imunoglobulin G metabolismus MeSH
- inbrední kmeny potkanů MeSH
- krevní objem účinky léků MeSH
- krysa rodu Rattus MeSH
- methylcelulosa toxicita MeSH
- počet erytrocytů MeSH
- počet trombocytů MeSH
- splenektomie MeSH
- stárnutí erytrocytů účinky léků MeSH
- vyšetření krevní srážlivosti MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- autoprotilátky MeSH
- erythropoetin MeSH
- imunoglobulin G MeSH
- methylcelulosa MeSH
Methyl cellulose syndrome induced by repeated i. p. injections of methyl cellulose (MC) was followed in experimental rats. Following application of 2--4 MC injections early haematological changes are observed including increased values of reticulocytes, development of serum aggregation factor having anti-erythrocyte antibody nature and altered filtrability of non-washed erythrocytes. Later alterations developing with further MC injections (8-32) are characterized by expressive splenic enlargement, by decrease in erythrocyte and platelet values and by additional increase in number of reticulocytes. The cause of anaemia is pooling and sequestration of erythrocytes in the spleen and haemodilution from hypervolaemia blood plasma. The decreased platelet amount is the result of reduced survival time of platelets due to their increased sequestration in the spleen. Haematological changes are normalized after splenectomy. This picture resembles to a great extent human hypersplenism.