Antibiotic production by submerged culture of Melanconis flavovirens (Otth) Wehm
Language English Country United States Media print
Document type Journal Article
PubMed
6790384
DOI
10.1007/bf02927367
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents biosynthesis pharmacology MeSH
- Ascomycota metabolism MeSH
- Bacillus subtilis drug effects MeSH
- Candida drug effects MeSH
- Nitrogen metabolism MeSH
- Culture Media MeSH
- Carbon metabolism MeSH
- Xylariales metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Nitrogen MeSH
- Culture Media MeSH
- Carbon MeSH
The pyrenomycete Melanconis flavovirens under submerged cultivation produced antibiotics active against both bacteria and fungi. Glucose and corn-steep liquor were the best C and N sources for the antibiotic production, respectively. Supplementation with Tween-80 and enthylene glycol stimulated both antifungal and antibacterial antibiotic production, whereas oleic acid only the antifungal one. Addition of K2HPO4 also showed a positive effect. The optimal conditions for fermentation of the antifungal component are given.
