Interaction of nystatin with nystatin-resistant Candida tropicalis
Language English Country United States Media print
Document type Journal Article
PubMed
6873771
DOI
10.1007/bf02884078
Knihovny.cz E-resources
- MeSH
- Biological Transport, Active drug effects MeSH
- Drug Resistance, Microbial MeSH
- Cell Membrane metabolism MeSH
- Candida drug effects genetics metabolism MeSH
- Energy Metabolism drug effects MeSH
- Ergosterol metabolism MeSH
- Membrane Lipids metabolism MeSH
- Nystatin metabolism pharmacology MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Ergosterol MeSH
- Membrane Lipids MeSH
- Nystatin MeSH
Nystatin-resistant yeast Candida tropicalis was obtained after UV illumination and plating on nystatin-containing media. The mutant contained no ergosterol in the plasma membrane but bound nystatin to a degree similar to that of the wild strain (1.2 vs. 1.5 nmol per mg dry solid). Respiration of the mutant on glucose was reduced by 36% in the presence of 25 microM nystatin. This corresponded to a 25-43% decrease of the uptake of monosaccharides. Transport of amino acids was reduced by nystatin in the mutant by 44-86%, as compared with a 84-95% reduction in the wild strain. The intracellular ATP content was reduced by nystatin equally in the wild strain and in the mutant (by 43 and 47%). Nystatin appears to affect specifically membrane transport processes of nonelectrolytes while both the H+-extruding ATPase and the membrane potential are unaffected.
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