Effect of substrates on the malonate inhibitory pattern and brefeldin A formation in Curvularia lunata
Language English Country United States Media print
Document type Journal Article
PubMed
7203283
DOI
10.1007/bf02927218
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents biosynthesis MeSH
- Brefeldin A MeSH
- Cyclopentanes biosynthesis MeSH
- Carboxylic Acids metabolism MeSH
- Malonates pharmacology MeSH
- Mitosporic Fungi drug effects growth & development metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Brefeldin A MeSH
- Cyclopentanes MeSH
- Carboxylic Acids MeSH
- Malonates MeSH
The extracellular level of brefeldin A fluctuates with the length of malonate inhibition. Following treatment with malonate, mycelial multiplication as opposed to brefeldin A formation, was preferentially increased in the maleate, fumarate, succinate, citrate, methyl palmitate and glucose replacement cultures. Competitive maleate--malonate, fumarate--malonate, succinate--malonate and citrate--malonate-inhibited replacement cultures gave significantly higher mycelial and brefeldin A yields than the sole malonate-inhibited replacement cultures.
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