Seizures elicited by subcutaneous injection of metrazol during ontogenesis in rats
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article
PubMed
7225195
Knihovny.cz E-resources
- MeSH
- Rats MeSH
- Pentylenetetrazole * administration & dosage MeSH
- Reaction Time MeSH
- Age Factors MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Pentylenetetrazole * MeSH
Metrazol administered subcutaneously at a dose of 80 mg . kg-1 elicited genuine minimal seizures (predominantly clonic) in adult, 45- and 25-day-old rats. The same dose of metrazol resulted in long-lasting generalized tonic-clonic seizures in rats aged 15 days and younger. Eighteen-day-old rats represented a transitory stage in which both types of seizures were present: minor seizures at first and then, after a short resting period, major seizures. A different seizure pattern in young rats was not induced by their higher sensitivity to metrazol, but was caused by the level of neural maturation.
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
Pentylenetetrazol-induced seizures in rats: an ontogenetic study
