Kainate/AMPA receptor antagonists are anticonvulsant against the tonic hindlimb component of pentylenetetrazol-induced seizures in developing rats
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
7617727
DOI
10.1016/0091-3057(94)00329-h
PII: 0091-3057(94)00329-H
Knihovny.cz E-resources
- MeSH
- 6-Cyano-7-nitroquinoxaline-2,3-dione pharmacology MeSH
- Receptors, AMPA antagonists & inhibitors MeSH
- Anticonvulsants pharmacology MeSH
- Quinoxalines pharmacology MeSH
- Behavior, Animal drug effects MeSH
- Epilepsy, Tonic-Clonic chemically induced prevention & control MeSH
- Rats MeSH
- Synaptic Transmission drug effects MeSH
- Pentylenetetrazole MeSH
- Rats, Wistar MeSH
- Receptors, Kainic Acid antagonists & inhibitors MeSH
- Aging physiology MeSH
- Muscle Tonus drug effects MeSH
- Seizures chemically induced prevention & control MeSH
- Hindlimb drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline MeSH Browser
- 6-Cyano-7-nitroquinoxaline-2,3-dione MeSH
- Receptors, AMPA MeSH
- Anticonvulsants MeSH
- Quinoxalines MeSH
- FG 9041 MeSH Browser
- Pentylenetetrazole MeSH
- Receptors, Kainic Acid MeSH
Non-NMDA receptor antagonists CNQX, DNQX, and NBQX (10-40 mg/kg IP) were tested against pentylenetetrazol-induced (100 mg/kg SC) seizures in 7 to 90-day-old rats. All three drugs significantly decreased the incidence of tonic hindlimb component of tonic-clonic pentylenetetrazol seizures, often in favor of increased incidence of forelimb tonus throughout development. In addition, in 7 to 25-day-old rats, DNQX and NBQX decreased the severity of seizures due to a decrease in total incidence of the tonic component of tonic-clonic seizures compared to age-matched controls. However, neither drug was able to consistently suppress the incidence or increase latency to onset of clonic and tonic-clonic pentylenetetrazol seizures. The data suggest that, during development, non-NMDA receptor transmission may play a role in the generation of the tonic component, but not in the generation of other components of pentylenetetrazol-induced seizures.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
