Mutants of dermatophytes resistant to ketoconazole
Acta Universitatis Palackianae Olomucensis Facultatis Medicae.
1994 ;
137 () :
15-7.
Language English Country Czech Republic Media print
Document type Journal Article
Persistent link
https://www.medvik.cz/link/pmid07778498
PubMed
7778498
Knihovny.cz E-resources
- MeSH
- Drug Resistance, Microbial MeSH
- Ketoconazole pharmacology MeSH
- Microsporum drug effects genetics MeSH
- Mutation MeSH
- Trichophyton drug effects genetics MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Ketoconazole MeSH
Authors describe the frequency and properties of mutants resistant to ketoconazole, obtained from the dermatophytes Microsporum gypseum and Trichophyton mentagrophytes. Spontaneous mutants occurred with the frequency of 10(-9) to spore and nucleus. Ultraviolet radiation increased the frequency of mutants by two numeric orders. The resistance level was relatively small in both types of mutants (RL within the range of 2-5).
