A group of 1000 random trephine biopsies were evaluated according to their usefulness for typing and staging of haematological tumours. Trephine biopsy contributed someway to clinical data in half the cases. Primary medullary processes showed an excellent correspondence of clinical and bioptical data. Biopsy contributed substantially to specification of myeloproliferations and myodysplasias. There were only 24% of negative results (descriptive inconclusive). Malignant lymphomas presented situation analogical to leucaemias. Peripherical malignant lymphomas in medulla mostly did not follow diversity of lymph node phenomena and did not contribute to more detailed typing but enabled satisfactory staging. Malignant lymphomas were located, unlike leucaemia, intertrabeculary or peritrabeculary and often induced reactive myeloproliferation or scarring. Biopsy was usually good for separation of medullary carcinosis. Remarks to technology of getting and processing of bioptical sample were discussed.

Hlavův 1 patologickoanatomický ústav 1 LF UK Praha