Effects of daunomycin and its macromolecular analog daunophilin on the proliferation of mammalian cells
Language English Country Slovakia Media print
Document type Comparative Study, Journal Article
PubMed
8350963
Knihovny.cz E-resources
- MeSH
- Cell Division drug effects MeSH
- Cell Line MeSH
- Time Factors MeSH
- Daunorubicin analogs & derivatives metabolism pharmacology MeSH
- Glioma pathology MeSH
- HeLa Cells MeSH
- Rats MeSH
- Humans MeSH
- Methacrylates metabolism MeSH
- Molecular Sequence Data MeSH
- Tumor Cells, Cultured MeSH
- Lung cytology embryology MeSH
- Amino Acid Sequence MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Daunorubicin MeSH
- daunophilin MeSH Browser
- hydroxypropyl methacrylate MeSH Browser
- Methacrylates MeSH
Effects of daunomycin and daunomycin bound to an HPMA copolymer (daunophilin) on the proliferation of mammalian cells cultivated in vitro were compared. One line of non-tumor cells (LEP human cells) and two tumor cell lines (human HeLa cells and C6 rat cells) were used. It was found that both daunomycin and daunophilin had an inhibitory effect on the proliferation of the three cell lines and that the effect was irreversible. Daunophilin had to be used in concentrations by two orders of magnitude higher (> 1 micrograms/ml) than daunomycin (> 0.01 micrograms/ml) to produce comparable effect on cell growth.
