c-myc gene activation as a permanent trait of RSV-infected quail cells
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
8386142
DOI
10.1002/ijc.2910530621
Knihovny.cz E-resources
- MeSH
- Transcriptional Activation MeSH
- Coturnix embryology microbiology MeSH
- Phenotype MeSH
- Genes, myc genetics MeSH
- Proto-Oncogene Proteins c-myc genetics metabolism MeSH
- Sarcoma, Avian genetics microbiology MeSH
- Gene Expression Regulation, Viral genetics MeSH
- Gene Expression Regulation, Neoplastic genetics MeSH
- Sensitivity and Specificity MeSH
- Temperature MeSH
- Cell Transformation, Viral genetics MeSH
- Avian Sarcoma Viruses genetics MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Proto-Oncogene Proteins c-myc MeSH
A high level of c-myc gene expression was found to be a constant feature of v-src transformation. The c-myc gene product was analyzed in quail embryo cells transformed by different mutants of Rous sarcoma virus (RSV) that were temperature-sensitive with respect to various parameters of v-src function. The high-level expression of c-myc proved not to be temperature-sensitive: at both permissive (35 degrees C) and non-permissive (41 degrees C) temperatures, the same high levels of c-myc gene product were found for all RSV mutants tested. This result, in agreement with earlier evidence for a v-src-induced proliferative stimulus which was unaffected by ts mutants at the non-permissive temperature, shows that certain v-src functions have not yet been fully characterized.
References provided by Crossref.org
Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells
