c-myc gene activation as a permanent trait of RSV-infected quail cells
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
8386142
DOI
10.1002/ijc.2910530621
Knihovny.cz E-zdroje
- MeSH
- aktivace transkripce MeSH
- Coturnix embryologie mikrobiologie MeSH
- fenotyp MeSH
- geny myc genetika MeSH
- protoonkogenní proteiny c-myc genetika metabolismus MeSH
- ptačí sarkom genetika mikrobiologie MeSH
- regulace exprese virových genů genetika MeSH
- regulace genové exprese u nádorů genetika MeSH
- senzitivita a specificita MeSH
- teplota MeSH
- virová transformace buněk genetika MeSH
- viry ptačího sarkomu genetika MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- protoonkogenní proteiny c-myc MeSH
A high level of c-myc gene expression was found to be a constant feature of v-src transformation. The c-myc gene product was analyzed in quail embryo cells transformed by different mutants of Rous sarcoma virus (RSV) that were temperature-sensitive with respect to various parameters of v-src function. The high-level expression of c-myc proved not to be temperature-sensitive: at both permissive (35 degrees C) and non-permissive (41 degrees C) temperatures, the same high levels of c-myc gene product were found for all RSV mutants tested. This result, in agreement with earlier evidence for a v-src-induced proliferative stimulus which was unaffected by ts mutants at the non-permissive temperature, shows that certain v-src functions have not yet been fully characterized.
Citace poskytuje Crossref.org
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