Anticonvulsant activity of flumazenil in rats during ontogenetic development
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
8451262
DOI
10.1016/0091-3057(93)90170-x
PII: 0091-3057(93)90170-X
Knihovny.cz E-zdroje
- MeSH
- antikonvulziva farmakologie MeSH
- epilepsie tonicko-klonická chemicky indukované prevence a kontrola MeSH
- flumazenil farmakologie MeSH
- krysa rodu Rattus MeSH
- pentylentetrazol MeSH
- potkani Wistar MeSH
- stárnutí fyziologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- záchvaty chemicky indukované prevence a kontrola MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antikonvulziva MeSH
- flumazenil MeSH
- pentylentetrazol MeSH
The influence of flumazenil on seizures induced by pentylenetetrazol (PTZ) was studied in rats aged 7, 12, 18, 25, and 90 days. Flumazenil in doses of 25, 37.5, and 50 mg/kg IP injected 10 min before PTZ exhibited a dose-dependent anticonvulsant action in all age groups studied. It was more effective against generalized tonic-clonic than against minimal clonic seizures at all developmental stages studied. In the two youngest groups, minimal seizures were elicited only rarely under control conditions. Pretreatment with the two lower doses of flumazenil resulted in an increased incidence of this type of seizure for these two groups. The anticonvulsant activity found in all age groups is in agreement with data from other benzodiazepines and speaks against a pure benzodiazepine-antagonistic action of flumazenil.
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