Interaction of bromine with iodine in the rat thyroid gland at enhanced bromide intake
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8909694
DOI
10.1007/bf02784432
Knihovny.cz E-resources
- MeSH
- Bromine metabolism pharmacokinetics MeSH
- Bromides administration & dosage metabolism pharmacokinetics MeSH
- Chlorine metabolism pharmacokinetics MeSH
- Iodine metabolism pharmacokinetics MeSH
- Rats MeSH
- Drug Interactions MeSH
- Rats, Wistar MeSH
- Thyroid Gland metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bromine MeSH
- Bromides MeSH
- Chlorine MeSH
- Iodine MeSH
In experiments with rats, we have found that at enhanced intake of bromide, bromine does not replace chlorine in the thyroid; it replaces iodine. Under our experimental conditions, more than one-third of the iodine content in the thyroid was replaced by bromine. In the thyroid, bromine probably remained in the form of bromide and, in proportional to its increased concentration, the production of iodinated thyronines decreased, with the sum of the iodine and bromine concentrations being constant at the value of 20.51 +/- 1.16 mumol/g dry wt of the thyroid. In contrast to other organs, the biological behavior of bromine in the thyroid is not similar to the biological behavior of chlorine but resembles more that of iodine.
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